Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREK-1 potassium channel / mechanosensing: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| KCNK2 | participates_in | gene | 0.42 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu | 0.437 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Novel function of TREK-1 in regulating adipocyte differentiation and lipid accum [PMID:40057491] | Kim A, Jung S, Kim Y, Jung J, Lee S, Lee | Cell Death Dis | 2025 | 1 |
| Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outf [PMID:41268978] | Redmon SN, Yarishkin O, Rudzitis CN, Lak | Invest Ophthalmol Vis Sci | 2025 | 1 |
| Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A- [PMID:36410022] | Zyrianova T, Lopez B, Zou K, Gu C, Pham | Am J Physiol Lung Cell Mol Phy | 2023 | 1 |
| Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci f [PMID:30061609] | Wyss AB, Sofer T, Lee MK, Terzikhan N, N | Nat Commun | 2018 | 1 |
| Temperature sensitivity of two-pore (K2P) potassium channels. [PMID:25366235] | Schneider ER, Anderson EO, Gracheva EO, | Curr Top Membr | 2014 | 1 |
| TREK-king the blood-brain-barrier. [PMID:24557892] | Bittner S, Ruck T, Fernández-Orth J, Meu | J Neuroimmune Pharmacol | 2014 | 1 |
| The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, [PMID:41226584] | ["Costea D", "Dobrin N", "Tataru C", "To | International journal of molec | 2025 | 0 |
| Genetic Insights into Brain Morphology: a Genome-Wide Association Study of Corti [PMID:40167904] | ["Kim N", "Chowdhury N", "Buetow K", "Th | Neuroinformatics | 2025 | 0 |
| Calcium-dependent activation of TREK-1 and TREK-2 background potassium channels [PMID:41457157] | Baukál D, Pergel E, Debreczeni D, Horvát | Scientific reports | 2025 | 0 |
| The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neu [PMID:25315980] | Göb E, Bittner S, Bobak N, Kraft P, Göbe | Pflugers Archiv : European jou | 2015 | 0 |
| Systemic mastocytosis in the elderly. [PMID:23436294] | ["Butterfield J", "Weiler C"] | American journal of hematology | 2013 | 0 |
| Carbon catabolite repression regulates amino acid permeases in Saccharomyces cer [PMID:16407266] | ["Peter G", "D\u00fcring L", "Ahmed A"] | The Journal of biological chem | 2006 | 0 |